CLP Implementation Dates

20 January 2015

CLP Regulation (EC) No 1272/2008 entered into force and progressively replaced:

  • the Directive 67/548/EEC on Classification, Packaging and Labelling of Dangerous Substances
  • the Directive 1999/45/EC on Classification, Packaging and Labelling of Dangerous Preparations


1 June 2015

Abrogation of Directives 67/548/EEC and 1999/45/EC


19 December 2022

Since its adoption, the regulation has been amended on several occasion, most recently by Commission Delegated Regulation (EU) 2023/707.

Most of the amendments that have been made are related to the regulation’s annexes.


You can check Tox by Design methodology for Safety Data Sheets, which are duly validated and signed by an European Registered Toxicologist expert.

In the event you are performing this exercise for innovative compounds GMP scale up manufacturing, please be noted that Tox by Design is duly accredited for the French Research Tax Credit CIR.

Feel free to contact us using the Quotation Request below to receive a quotation for Safety Data Sheet for any Chemicals substances deployed in your GMP manufacturing lines.